Cancers, Free Full-Text
Por um escritor misterioso
Last updated 05 julho 2024
![Cancers, Free Full-Text](https://pub.mdpi-res.com/cancers/cancers-14-04262/article_deploy/html/images/cancers-14-04262-g005.png?1661999222)
Ubiquitin-like, containing PHD and RING finger domain, (UHRF) family members are overexpressed putative oncogenes in several cancer types. We evaluated the protein abundance of UHRF family members in acute leukemia. A marked overexpression of UHRF1 protein was observed in ALL compared with AML. An analysis of human leukemia transcriptomic datasets revealed concordant overexpression of UHRF1 in B-Cell and T-Cell ALL compared with CLL, AML, and CML. In-vitro studies demonstrated reduced cell viability with siRNA-mediated knockdown of UHRF1 in both B-ALL and T-ALL, associated with reduced c-Myc protein expression. Mechanistic studies indicated that UHRF1 directly interacts with c-Myc, enabling ALL expansion via the CDK4/6-phosphoRb axis. Our findings highlight a previously unknown role of UHRF1 in regulating c-Myc protein expression and implicate UHRF1 as a potential therapeutic target in ALL.
![Cancers, Free Full-Text](https://acsjournals.onlinelibrary.wiley.com/cms/asset/cda39a9d-7a4e-4d2d-99ca-28e7d1a12b34/caac21660-fig-0001-m.jpg)
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and
from Flow Cytometry to Cytomics, Page 2
27+ Cancer Pictures Download Free Images & Stock Photos on Unsplash
![Cancers, Free Full-Text](https://www.thelancet.com/cms/asset/9f7c134d-31b6-46e1-bbc7-bf424da41e73/gr1.jpg)
Predicting peritoneal recurrence and disease-free survival from CT
Flow Cytometric Analysis Of Several Cancer Cell Lines Breast
![Cancers, Free Full-Text](https://i.etsystatic.com/16309928/r/il/f12aac/2093828252/il_570xN.2093828252_rzv7.jpg)
10 Year Cancer Survivor Card Remission Card Cancer Free Card
![Cancers, Free Full-Text](https://www.pathologyoutlines.com/pathout_uploads/2023/12/Roche_Stomach-Side_231201.jpg)
Pathology Outlines - Carcinoma-general
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