Expanding the Scope of RNA Metabolic Labeling with Vinyl

An optimized chemical-genetic method for cell-specific metabolic labeling of RNA

Bioorthogonal chemistry-based RNA labeling technologies: evolution and current state - Chemical Communications (RSC Publishing) DOI:10.1039/D0CC05228K

Hybridization-Sensitive Fluorescent Probes for DNA and RNA by a Modular “Click” Approach - ScienceDirect

An optimized chemical-genetic method for cell-specific metabolic labeling of RNA

A) Concept of metabolic RNA labeling. Nucleosides with small

Covalent labeling of nucleic acids - Chemical Society Reviews (RSC Publishing) DOI:10.1039/D0CS00600A

Labelling of DNA and RNA in the cellular environment by means of bioorthogonal cycloaddition chemistry - RSC Chemical Biology (RSC Publishing) DOI:10.1039/D0CB00047G

Expanding the Scope of RNA Metabolic Labeling with Vinyl Nucleosides and Inverse Electron-Demand Diels–Alder Chemistry

Time-resolved single-cell RNA-seq using metabolic RNA labelling

Exploiting Endogenous Enzymes for Cancer-Cell Selective Metabolic Labeling of RNA in Vivo

A) Schematic representation of the labelling strategy. Vinyl-modified

DNA templated Click Chemistry via 5-vinyl-2′-deoxyuridine and an acridine-tetrazine conjugate induces DNA damage and apoptosis in cancer cells - ScienceDirect

Probing Nascent RNA with Metabolic Incorporation of Modified Nucleosides

A) Schematic representation of the labelling strategy. Vinyl-modified