Genes, Free Full-Text
Por um escritor misterioso
Last updated 07 julho 2024
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Background: Hemochromatosis is a genetic condition of iron overload caused by deficiency of hepcidin. In a previous stage of this study, patients with suspected hemochromatosis had their quality of life (QL) measured. We observed that QL scores differed among genotypic groups of patients. In this reported final phase of the study, the aims were to compare QL scores after a treatment period of approximately 3 years and to analyze a possible association of the serum ferritin values with QL scores. Methods: Sixty-five patients were enrolled in this final phase and divided into group 1 (patients that showed primary iron overload and homozygous genotype for the HFE p.Cys282Tyr mutation) and group 2 (other kinds of genotypes). Short Form 36 (SF-36) was performed and consisted of eight domains with a physical and also a mental component. Results: Both groups had a significant decrease in serum ferritin concentrations: group 1 had a variation from 1844 ± 1313 ng/mL to 281 ± 294 ng/mL, and group 2 had a variation from 1216 ± 631 ng/mL to 236 ± 174 ng/mL. Group 1 had a smaller mean value for these six SF-36 domains compared with group 2, indicating a worse QL. Conclusions: In this final stage, six domains demonstrated a difference among genotypic groups (role emotional and mental health, adding to the four of the initial phase), reassuring the impact of the identified genotype on the QL of hemochromatosis patients. Furthermore, despite that both patient groups demonstrated similar and significant decreases in serum ferritin values, no association was found between the decrease in this biological parameter and the SF-36 domains.
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Cytoscape 3.0.2 Get File - Colaboratory
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Exploring the potential mechanisms of action for HF and SLE
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Basu Basu Pardesi Nenu Song Free - Colaboratory
Hartwell Genetics From Genes To Genomes 4th Txtbk : Free Download, Borrow, and Streaming : Internet Archive
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Philosophies, Free Full-Text
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Genes, Free Full-Text
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Frontiers Transgene-free Genome Editing in Plants
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The complete sequence of a human genome
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Genes April 2022 - Browse Articles
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BioCyc Pathway/Genome Database Collection
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Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A
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Inferring gene expression from cell-free DNA fragmentation profiles
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genesis - Wiley Online Library
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