Toxins, Free Full-Text
Por um escritor misterioso
Last updated 08 julho 2024
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L-Amino acid oxidase (LAAO) is an enzyme found in snake venom that has multifaceted effects, including the generation of hydrogen peroxide (H2O2) during oxidative reactions, leading to various biological and pharmacological outcomes such as apoptosis, cytotoxicity, modulation of platelet aggregation, hemorrhage, and neutrophil activation. Human neutrophils respond to LAAO by enhancing chemotaxis, and phagocytosis, and releasing reactive oxygen species (ROS) and pro-inflammatory mediators. Exosomes cellular nanovesicles play vital roles in intercellular communication, including immune responses. This study investigates the impact of Calloselasma rhodostoma snake venom-derived LAAO (Cr-LAAO) on human neutrophil exosome release, including activation patterns, exosome formation, and content. Neutrophils isolated from healthy donors were stimulated with Cr-LAAO (100 μg/mL) for 3 h, followed by exosome isolation and analysis. Results show that Cr-LAAO induces the release of exosomes with distinct protein content compared to the negative control. Proteomic analysis reveals proteins related to the regulation of immune responses and blood coagulation. This study uncovers Cr-LAAO’s ability to activate human neutrophils, leading to exosome release and facilitating intercellular communication, offering insights into potential therapeutic approaches for inflammatory and immunological disorders.
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Pollution and health: a progress update - The Lancet Planetary Health
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Body detoxification, Health, Detoxification
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Abgt 100 Get File - Colaboratory
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Frontiers Strategies for Heterologous Expression, Synthesis, and Purification of Animal Venom Toxins
GMO/Toxin Free USA - Get the full test results here: When people buy green beauty products, they expect they're not going to contain harmful toxins and known carcinogens! A consumer watchdog
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Detox Complete (Clinical Synergy)
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Toxic warning alert: Food Babe's new book full of chemicals - Genetic Literacy Project
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Toxins, Free Full-Text
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Bacillus thuringiensis toxins divert progenitor cells toward enteroendocrine fate by decreasing cell adhesion with intestinal stem cells in Drosophila
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Type II Toxin-Antitoxin Systems: Evolution and Revolutions
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Ultimate Toxin Free Cleaning Switch List - Healthy House on the Block
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