Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet
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Last updated 28 junho 2024
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Full article: New pharmacotherapeutic options for oral
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Treatment Effect on Stroke Subtypes According to TOAST (Trial of
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://ars.els-cdn.com/content/image/1-s2.0-S1538783623003434-gr1.jpg)
News at XI: moving beyond factor Xa inhibitors - ScienceDirect
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.jacc.org/cms/asset/24eb4ecf-f037-449e-a726-2ebc8e27cb77/ga1.jpg)
Antithrombotic Therapy for Primary and Secondary Prevention of
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://pubs.acs.org/cms/10.1021/acs.jmedchem.3c00795/asset/images/medium/jm3c00795_0002.gif)
Design and Preclinical Characterization Program toward Asundexian
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://pubs.acs.org/cms/10.1021/acs.jmedchem.3c00795/asset/images/medium/jm3c00795_0009.gif)
Design and Preclinical Characterization Program toward Asundexian
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs00281-023-00994-4/MediaObjects/281_2023_994_Fig2_HTML.png)
Thromboinflammatory challenges in stroke pathophysiology
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://pub.mdpi-res.com/jcdd/jcdd-10-00164/article_deploy/html/images/jcdd-10-00164-g001.png?1681129144)
JCDD, Free Full-Text
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://accp1.onlinelibrary.wiley.com/cms/asset/f718a88b-dd36-4bab-9c88-8a2547a3e52a/cpdd1207-fig-0001-m.jpg)
Effects of Tablet Formulation, Food, or Gastric pH on the
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://i1.rgstatic.net/publication/373459828_Efficacy_and_Safety_of_Oral_Factor_XIa_Inhibitors_in_Stroke_Prevention_A_Systematic_Review_and_Meta-Analysis/links/64ede6afe081b872fd07cd96/largepreview.png)
PDF) Efficacy and Safety of Oral Factor XIa Inhibitors in Stroke
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://journals.sagepub.com/cms/10.1177/23969873231174942/asset/images/large/10.1177_23969873231174942-fig3.jpeg)
Ischaemic stroke despite antiplatelet therapy: Causes and outcomes
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.ahajournals.org/cms/asset/910052e3-66f8-4b29-a62d-7eae6cfbd9ef/strokeaha.122.042233.fig03.jpg)
Dual Antiplatelet Therapies and Causes in Minor Stroke or
(BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.glpbio.com/media/struct/GC6/GC65912.png)
Asundexian
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.ahajournals.org/cms/asset/87af4ef2-d9a1-4f14-bd6e-1ff8a50fe676/circulationaha.122.061612.fig02.jpg)
A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double
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