CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs: Molecular Therapy - Nucleic Acids
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Last updated 16 junho 2024
![CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs: Molecular Therapy - Nucleic Acids](https://www.cell.com/cms/attachment/eea8ce0e-5d6d-4f9b-88a4-f317680697a5/gr4_lrg.jpg)
![CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs: Molecular Therapy - Nucleic Acids](https://ars.els-cdn.com/content/image/1-s2.0-S1931524423000257-gr1.jpg)
CRISPR/Cas9-mediated A4GALT suppression rescues Fabry disease
![CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs: Molecular Therapy - Nucleic Acids](https://www.cell.com/cms/attachment/eea8ce0e-5d6d-4f9b-88a4-f317680697a5/gr4_lrg.jpg)
CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores
![CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs: Molecular Therapy - Nucleic Acids](https://ars.els-cdn.com/content/image/1-s2.0-S1931524423000257-gr4.jpg)
CRISPR/Cas9-mediated A4GALT suppression rescues Fabry disease
![CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs: Molecular Therapy - Nucleic Acids](https://media.springernature.com/lw685/springer-static/image/chp%3A10.1007%2F164_2023_642/MediaObjects/531913_1_En_642_Fig2_HTML.png)
Retinal Ganglion Cells in a Dish: Current Strategies and
![CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs: Molecular Therapy - Nucleic Acids](https://www.frontiersin.org/files/Articles/627050/fgene-12-627050-HTML/image_m/fgene-12-627050-g001.jpg)
Frontiers Adapting CRISPR/Cas9 System for Targeting
![CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs: Molecular Therapy - Nucleic Acids](https://www.ahajournals.org/cms/asset/20b8e279-ef5f-454d-9902-4cd7dc008989/jah388-fig-0001.gif)
OPA1 Mutation and Late‐Onset Cardiomyopathy: Mitochondrial
![CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs: Molecular Therapy - Nucleic Acids](https://www.biorxiv.org/content/biorxiv/early/2023/03/20/2023.03.17.533056/F3.large.jpg)
Drosophila model to clarify the pathological significance of OPA1
![CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs: Molecular Therapy - Nucleic Acids](https://static.hindawi.com/articles/omcl/volume-2023/7718155/figures/7718155.fig.006c.jpg)
Melatonin Repairs Osteoporotic Bone Defects in Iron-Overloaded
![CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs: Molecular Therapy - Nucleic Acids](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41431-022-01102-0/MediaObjects/41431_2022_1102_Fig4_HTML.png)
Characterisation of a novel OPA1 splice variant resulting in
![CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs: Molecular Therapy - Nucleic Acids](https://www.mdpi.com/ijms/ijms-23-11482/article_deploy/html/images/ijms-23-11482-g001.png)
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