Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer
Por um escritor misterioso
Last updated 17 junho 2024
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs12885-023-10501-5/MediaObjects/12885_2023_10501_Fig3_HTML.png)
Background The link between immediate hypersensitivity reactions (HSR) following the first cetuximab infusion and the IgE sensitization against anti-galactose-α-1,3-galactose (α-Gal) is now well-established. An automated Fluoroenzyme-Immunoassay (FEIA) is available and may facilitate the screening of patients with anti-α-Gal IgE before treatment. Methods This study aimed to evaluate its performances as compared to a previously validated anti-cetuximab IgE ELISA, using 185 samples from two previously studied cohorts. Results Despite 21.1% of discrepancies between the two techniques, FEIA discriminated better positive patients and similarly negative ones with a ≥ 0.525 kUA/L threshold. Sensitivity was 87.5% for both tests, specificity was better for FEIA (96.3% vs ELISA: 82.1%). FEIA had a higher positive likelihood ratio (23.9 vs ELISA: 4.89) and a similar negative likelihood ratio (0.13 vs ELISA: 0.15). In our population, the risk of severe HSR following a positive test was higher with FEIA (56.7% vs ELISA: 19.6%) and similar following a negative test (0.7% vs ELISA: 0.8%). Conclusion Although the predictive value of the IgE screening before cetuximab infusion remains discussed, this automated commercial test can identify high-risk patients and is suitable for routine use in laboratories. It could help avoiding cetuximab-induced HSR by a systematic anti-α-Gal IgE screening before treatment.
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://www.frontiersin.org/files/Articles/841564/fmars-09-841564-HTML/image_m/fmars-09-841564-g001.jpg)
Frontiers Characterization of a Diguanylate Cyclase VAGM001033 of Vibrio alginolyticus and Protective Efficacy as a Live Attenuated Vaccine Candidate in Pearl Gentian Grouper
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41598-020-78497-7/MediaObjects/41598_2020_78497_Fig3_HTML.png)
The role of IgE specific for galactose-α-1,3-galactose in predicting cetuximab induced hypersensitivity reaction: a systematic review and a diagnostic meta-analysis
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://www.researchgate.net/profile/Delphine-Mariotte-2/publication/51202354/figure/tbl1/AS:667823126900736@1536232849036/Patient-characteristics-n-92_Q320.jpg)
PDF) Anti-cetuximab IgE ELISA for identification of patients at high risk of cetuximab-induced anaphylaxis
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://www.researchgate.net/profile/Julien-Serrier/publication/366965056/figure/fig2/AS:11431281113053520@1673667163405/Specificity-of-anti-a-Gal-IgE-fluoroenzyme-immunoassay-FEIA-ImmunoCap-o215-tests-were_Q320.jpg)
PDF) Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://www.researchgate.net/publication/51202354/figure/fig1/AS:639545410338824@1529490916714/Prevalence-of-anti-cetuximab-IgE-IgE-levels-were-measured-in-serum-samples-from-a.png)
Prevalence of anti-cetuximab IgE. IgE levels were measured in serum
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://www.ahajournals.org/cms/asset/9e61f0e5-67ce-4b72-a37c-27c813d5dcbe/1665ga1.jpg)
IgE to the Mammalian Oligosaccharide Galactose-α-1,3-Galactose Is Associated With Increased Atheroma Volume and Plaques With Unstable Characteristics—Brief Report
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://www.future-science.com/cms/10.4155/bio.14.153/asset/images/medium/figure1.gif)
Allergen screening bioassays: recent developments in lab-on-a-chip and lab-on-a-disc systems
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs15007-020-2567-5/MediaObjects/15007_2020_2567_Fig1_HTML.jpg)
Hypersensitivity reactions to biologics (part II): classifications and current diagnostic and treatment approaches*
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs15007-020-2550-1/MediaObjects/15007_2020_2550_Fig1_HTML.jpg)
Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in complex immune-derived adverse events*
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://media.cheggcdn.com/study/294/29481be3-c9ff-4432-af0a-c14273fec77b/image.png)
Solved Based on the information shown in the previous
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41385-019-0159-z/MediaObjects/41385_2019_159_Fig6_HTML.png)
Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://i1.rgstatic.net/publication/264462937_Case_Report_About_Fatal_or_Near-Fatal_Hypersensitivity_Reactions_to_Cetuximab_Anticetuximab_IgE_as_a_Valuable_Screening_Test/links/6429a60066f8522c38f03562/largepreview.png)
(PDF) Case Report About Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://www.researchgate.net/profile/Jean-Michel-Grellard/publication/264462937/figure/tbl1/AS:11431281135283969@1680451142044/Case-descriptions_Q320.jpg)
PDF) Case Report About Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://kentlabs.com/wp-content/uploads/2017/03/FITC-Conjugates-human-IgA.jpg)
Anti Human IgA FITC (alpha chain specific)
Recomendado para você
-
Boneca de pano Elsa – Frozen17 junho 2024
-
Elsa, de Frozen: a rainha que resume todas as princesas Disney (e as mulheres)17 junho 2024
-
15 razões para as pessoas desistirem de uma vez por todas dos bolos de Frozen17 junho 2024
-
transformando princesas da disney ana|TikTok Search17 junho 2024
-
Memetizando – Página: Array – Acabando com a sua produtividade – Blog de Humor – Tirinhas – Gifs – Prints Engraçados – Videos engraçados e memes do Brasil.17 junho 2024
-
Pin em Stranger things personagens17 junho 2024
-
Tree Buddees King Kong Climbing The Tree Funny Christmas Tree Topper - Large 10 : Home & Kitchen17 junho 2024
-
Disney's Frozen Elsa Figure17 junho 2024
-
Boneca Feia em Promoção na Shopee Brasil 202317 junho 2024
-
Chinês de cara feia - Dinheiro Rural17 junho 2024
você pode gostar
-
MIAA releases first MIAA high school hockey tournament power rankings17 junho 2024
-
Cobian Sumo Terra Sandals for Men17 junho 2024
-
Carros na Web, Volkswagen T-CROSS17 junho 2024
-
46 Kabaneri of the iron fortress ideas in 202317 junho 2024
-
A Máquina de Doces de Du, Dudu e Edu17 junho 2024
-
FIFA reconhece o Brasil como maior vencedor da Copa do Mundo Sub-17 - Confederação Brasileira de Futebol17 junho 2024
-
High-Class Decks (TCG) - Bulbapedia, the community-driven Pokémon17 junho 2024
-
Full New Anime Movies in English Dubbed HD APK Download 202317 junho 2024
-
JXK 1/6 Mini Bully Dog Model Animal American Bully Pitbull Toy Collector Decor17 junho 2024
-
Recolhedora de cafe conilon Robusta Pinhalense #robusta #agro #agrobo17 junho 2024